Structural basis of substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase

Isocitrate dehydrogenase kinase/phosphatase (AceK) regulates entry into the glyoxylate bypass by reversibly phosphorylating isocitrate dehydrogenase (ICDH). Based on the recent complex structure of AceK-ICDH from E. coli, we have classified the structures of homodimeric NADP(+)-ICDHs to rationalize...

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Auteurs principaux: Yates, Susan P., Edwards, Thomas E., Bryan, Cassie M., Stein, Adam J., Van Voorhis, Wesley C., Myler, Peter J., Stewart, Lance J., Zheng, Jimin, Jia, Zongchao
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354702/
https://ncbi.nlm.nih.gov/pubmed/21870819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200809p
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