An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs

Preservation of the epithelial state involves the stable repression of epithelial-to-mesenchymal transition program, whereas maintenance of the stem compartment requires the inhibition of differentiation processes. A simple and direct molecular mini-circuitry between master elements of these biologi...

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Autori principali: Garibaldi, F, Cicchini, C, Conigliaro, A, Santangelo, L, Cozzolino, A M, Grassi, G, Marchetti, A, Tripodi, M, Amicone, L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354047/
https://ncbi.nlm.nih.gov/pubmed/22139130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.175
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