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A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin combines superb potency and lipophilicity with low toxicity

The Mn porphyrins of k(cat)(O(2)˙(−)) as high as that of a superoxide dismutase enzyme, and of optimized lipophilicity have already been synthesized. Their exceptional in vivo potency is at least in part due to their ability to mimic site and location of mitochondrial superoxide dismutase, MnSOD. Mn...

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Bibliografiske detaljer
Main Authors: Rajic, Zrinka, Tovmasyan, Artak, Spasojevic, Ivan, Sheng, Huaxin, Lu, Miaomiao, Li, Alice M., Gralla, Edith B., Warner, David S., Benov, Ludmil, Batinic-Haberle, Ines
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353805/
https://ncbi.nlm.nih.gov/pubmed/22336516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.006
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