PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice

Mineralocorticoid excess increases superoxide production by activating NADPH oxidase (NOX), and intracerebroventricular infusions of NADPH oxidase inhibitors attenuate aldosterone (Aldo)/salt-induced hypertension. It has been hypothesized that increased reactive oxygen species (ROS) in the brain may...

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Détails bibliographiques
Auteurs principaux: Xue, Baojian, Beltz, Terry G., Johnson, Ralph F., Guo, Fang, Hay, Meredith, Johnson, Alan Kim
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
Sujets:
Cardiovascular Neurohormonal Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353786/
https://ncbi.nlm.nih.gov/pubmed/22140041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00873.2011
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