Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations

Sleep–wake cycles break down with age, but the causes of this degeneration are not clear. Using a Drosophila model, we addressed the contribution of circadian mechanisms to this age-induced deterioration. We found that in old flies, free-running circadian rhythms (behavioral rhythms assayed in const...

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Detalhes bibliográficos
Main Authors: Luo, Wenyu, Chen, Wen-Feng, Yue, Zhifeng, Chen, Dechun, Sowcik, Mallory, Sehgal, Amita, Zheng, Xiangzhong
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353743/
https://ncbi.nlm.nih.gov/pubmed/22268765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00800.x
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