Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non Small Cell Lung Cancer

Epigenetic alterations are strongly associated with cancer development. We conducted a phase I/II trial of combined epigenetic therapy with azacitidine and entinostat, inhibitors of DNA methylation and histone deacetylation, respectively, in extensively pretreated patients with recurrent metastatic...

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Detalhes bibliográficos
Main Authors: Juergens, Rosalyn A., Wrangle, John, Vendetti, Frank P., Murphy, Sara C., Zhao, Ming, Coleman, Barbara, Sebree, Rosa, Rodgers, Kristen, Hooker, Craig M., Franco, Noreli, Lee, Beverly, Tsai, Salina, Delgado, Igor Espinoza, Rudek, Michelle A., Belinsky, Steven A., Herman, James G., Baylin, Stephen B., Brock, Malcolm V., Rudin, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353724/
https://ncbi.nlm.nih.gov/pubmed/22586682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0214
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