Early Changes in Interferon Signaling Define Natural Killer Cell Response and Refractoriness To Interferon-based Therapy of Hepatitis C

Natural killer (NK) cells exhibit a polarized phenotype with increased cytotoxicity and decreased IFN- γ production in chronic hepatitis C virus (HCV) infection. Here we asked whether this is due to type I interferon (IFN)-induced expression and phosphorylation levels of signal transducer and activa...

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Autores principales: Edlich, Birgit, Ahlenstiel, Golo, Azpiroz, Aintzane Zabaleta, Stoltzfus, Jonathan, Noureddin, Mazen, Serti, Elisavet, Feld, Jordan J., Liang, T. Jake, Rotman, Yaron, Rehermann, Barbara
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353526/
https://ncbi.nlm.nih.gov/pubmed/21898483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24628
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