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Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues.

The synthesis of the deoxynucleoside derived from the base P, 6H,8H-3,4-dihydro-pyrimido[4,5-c] [4,5-c] [1,2]oxazin-7-one, 2, and its introduction by established phosphoramidite and H-phosphonate chemistry into oligonucleotides is described. The melting transition temperatures (Tm) of a range of hep...

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Detalles Bibliográficos
Autores principales: Lin, P K, Brown, D M
Formato: Artigo
Lenguaje:Inglês
Publicado: 1989
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC335307/
https://ncbi.nlm.nih.gov/pubmed/2602155
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