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Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues.
The synthesis of the deoxynucleoside derived from the base P, 6H,8H-3,4-dihydro-pyrimido[4,5-c] [4,5-c] [1,2]oxazin-7-one, 2, and its introduction by established phosphoramidite and H-phosphonate chemistry into oligonucleotides is described. The melting transition temperatures (Tm) of a range of hep...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1989
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC335307/ https://ncbi.nlm.nih.gov/pubmed/2602155 |
| Etiquetas: |
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