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Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression
Urea is an endogenous metabolite, known to enhance stratum corneum hydration. Yet, topical urea anecdotally also improves permeability barrier function, and it appears to exhibit antimicrobial activity. Hence, we hypothesized that urea is not merely a passive metabolite, but a small-molecule regulat...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3352965/ https://ncbi.nlm.nih.gov/pubmed/22418868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.42 |
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