Functional Consequences of Mitochondrial DNA Deletions in Human Skin Fibroblasts : Increased Contractile Strength in Collagen Lattices Is Due to Oxidative Stress-Induced Lysyl Oxidase Activity

Deletions within the mitochondrial DNA (mtDNA) are thought to contribute to extrinsic skin aging. To study the translation of mtDNA deletions into functional and structural changes in the skin, we seeded human skin fibroblasts into collagen gels to generate dermal equivalents. These cells were eithe...

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Détails bibliographiques
Auteurs principaux: Majora, Marc, Wittkampf, Tanja, Schuermann, Bianca, Schneider, Maren, Franke, Susanne, Grether-Beck, Susanne, Wilichowski, Ekkehard, Bernerd, Françoise, Schroeder, Peter, Krutmann, Jean
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2009
Sujets:
Regular Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731121/
https://ncbi.nlm.nih.gov/pubmed/19661442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080832
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