Mechanisms and Evolutionary Patterns of Mammalian and Avian Dosage Compensation

As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexp...

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Main Authors: Julien, Philippe, Brawand, David, Soumillon, Magali, Necsulea, Anamaria, Liechti, Angélica, Schütz, Frédéric, Daish, Tasman, Grützner, Frank, Kaessmann, Henrik
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352821/
https://ncbi.nlm.nih.gov/pubmed/22615540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001328
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