Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor

We investigated the molecular mechanisms of cell cycle arrest and apoptotic death induced by Solanum lyratum extracts (SLE) or diosgenin in WEHI-3 murine leukemia cells in vitro and antitumor activity in vivo. Diosgenin is one of the components of SLE. Our study showed that SLE and diosgenin decreas...

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Autors principals: Yang, Jai-Sing, Wu, Chia-Chun, Kuo, Chao-Lin, Lan, Yu-Hsuan, Yeh, Chin-Chung, Yu, Chien-Chih, Lien, Jin-Cherng, Hsu, Yuan-Man, Kuo, Wei-Wen, Wood, W. Gibson, Tsuzuki, Minoru, Chung, Jing-Gung
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352350/
https://ncbi.nlm.nih.gov/pubmed/22611426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/254960
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