Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice

The present study was to explore the biological responses of the newly compound, MJ-29 in murine myelomonocytic leukemia WEHI-3 cells in vitro and in vivo fates. We focused on the in vitro effects of MJ-29 on ER stress and mitochondria-dependent apoptotic death in WEHI-3 cells, and to hypothesize th...

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Bibliographische Detailangaben
Hauptverfasser: Lu, Chi-Cheng, Yang, Jai-Sing, Chiang, Jo-Hua, Hour, Mann-Jen, Lin, Kuei-Li, Lin, Jen-Jyh, Huang, Wen-Wen, Tsuzuki, Minoru, Lee, Tsung-Han, Chung, Jing-Gung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360742/
https://ncbi.nlm.nih.gov/pubmed/22662126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036831
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