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Production of baculovirus defective interfering particles during serial passage is delayed by removing transposon target sites in fp25k

Accumulation of baculovirus defective interfering particle (DIP) and few polyhedra (FP) mutants is a major limitation to continuous large-scale baculovirus production in insect-cell culture. Although overcoming these mutations would result in a cheaper platform for producing baculovirus biopesticide...

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Detalhes bibliográficos
Main Authors: Giri, Lopamudra, Feiss, Michael G., Bonning, Bryony C., Murhammer, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352349/
https://ncbi.nlm.nih.gov/pubmed/21994323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.036566-0
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