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Structural modelling and mutagenesis of human cytomegalovirus alkaline nuclease UL98

Human cytomegalovirus encodes an alkaline nuclease, UL98, that is highly conserved among herpesviruses and has both endonuclease (endo) and exonuclease (exo) activities. This protein is thought to be important for viral replication and therefore represents a potential target for antiviral developmen...

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Detalhes bibliográficos
Main Authors: Kuchta, Alison L., Parikh, Hardik, Zhu, Yali, Kellogg, Glen E., Parris, Deborah S., McVoy, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352332/
https://ncbi.nlm.nih.gov/pubmed/21900421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.034876-0
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