Structural modelling and mutagenesis of human cytomegalovirus alkaline nuclease UL98

Human cytomegalovirus encodes an alkaline nuclease, UL98, that is highly conserved among herpesviruses and has both endonuclease (endo) and exonuclease (exo) activities. This protein is thought to be important for viral replication and therefore represents a potential target for antiviral developmen...

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Bibliographic Details
Main Authors: Kuchta, Alison L., Parikh, Hardik, Zhu, Yali, Kellogg, Glen E., Parris, Deborah S., McVoy, Michael A.
Format: Artigo
Language:Inglês
Published: Society for General Microbiology 2012
Subjects:
Animal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352332/
https://ncbi.nlm.nih.gov/pubmed/21900421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.034876-0
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