JC virus granule cell neuronopathy is associated with VP1 C terminus mutants

The polyomavirus JC (JCV) infects glial cells and causes progressive multifocal leukoencephalopathy (PML). We described a novel JCV-variant with a 10 bp deletion in the C terminus of the VP1 capsid protein, JCV(GCN1). This mutant was associated with lytic infection of cerebellar granule cell neurons...

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Autors principals: Dang, Xin, Vidal, Jose E., Penalva de Oliveira, Augusto C., Simpson, David M., Morgello, Susan, Hecht, Jonathan H., Ngo, Long H., Koralnik, Igor J.
Format: Artigo
Idioma:Inglês
Publicat: Society for General Microbiology 2012
Matèries:
Animal
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352331/
https://ncbi.nlm.nih.gov/pubmed/21940415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.037440-0
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