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The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing by the piRNA-PIWI system

BACKGROUND: A defense system against transposon activity in the human germline based on PIWI proteins and piRNA has recently been discovered. It represses the activity of LINE-1 elements via DNA methylation by a largely unknown mechanism. Based on the dispersed distribution of clusters of piRNA gene...

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Bibliografske podrobnosti
Main Authors: Sigurdsson, Martin I, Smith, Albert V, Bjornsson, Hans T, Jonsson, Jon J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352111/
https://ncbi.nlm.nih.gov/pubmed/22530917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-13-31
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