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Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
BACKGROUND: Glutathione (GSH) plays an important role in neuronal oxidant defence. Depletion of cellular GSH is observed in neurodegenerative diseases and thereby contributes to the associated oxidative stress and Ca(2+ )dysregulation. Whether depletion of cellular GSH, associated with neuronal sene...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3352021/ https://ncbi.nlm.nih.gov/pubmed/22487454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-5-11 |
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