Strong structural effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.
The NarI restriction enzyme recognition site, G1G2CG3CC, has been identified as a hotspot for -2 frameshift mutations induced by N-2-acetylaminofluorene (AAF) on the basis of a forward mutation assay in plasmid pBR322 in the bacterium Escherichia coli. AAF binds primarily to the C-8 position of guan...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1989
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| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC335195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2602135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.23.9531 |
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