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Strong structural effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.

The NarI restriction enzyme recognition site, G1G2CG3CC, has been identified as a hotspot for -2 frameshift mutations induced by N-2-acetylaminofluorene (AAF) on the basis of a forward mutation assay in plasmid pBR322 in the bacterium Escherichia coli. AAF binds primarily to the C-8 position of guan...

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Bibliografische gegevens
Hoofdauteurs: Koehl, P, Valladier, P, Lefèvre, J F, Fuchs, R P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1989
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC335195/
https://ncbi.nlm.nih.gov/pubmed/2602135
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