Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation

The Wnt/β-catenin pathway plays important roles in the differentiation of multiple cell types, including mesenchymal stem cells. Using a cell-based chemical screening assay with a synthetic chemical library of 270 000 compounds, we identified the compound SKL2001 as a novel agonist of the Wnt/β-cate...

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Main Authors: Gwak, Jungsug, Hwang, Sun Gwan, Park, Hyung-Soon, Choi, Sang Rak, Park, Sun-Hee, Kim, Hyunjoon, Ha, Nam-Chul, Bae, Sung Jin, Han, Jin-Kwan, Kim, Dong-Eun, Cho, Jeong Woo, Oh, Sangtaek
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2012
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351914/
https://ncbi.nlm.nih.gov/pubmed/21826110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.127
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