Species-Dependent Post-Transcriptional Regulation of NOS1 by FMRP in the Developing Cerebral Cortex

Fragile X syndrome (FXS), the leading monogenic cause of intellectual disability and autism, results from loss of function of the RNA-binding protein FMRP. Here we show that FMRP regulates the translation of neuronal nitric oxide synthase 1 (NOS1) in the developing human neocortex. Whereas NOS1 mRNA...

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Main Authors: Kwan, Kenneth Y., Lam, Mandy M. S., Johnson, Matthew B., Dube, Umber, Shim, Sungbo, Rašin, Mladen-Roko, Sousa, André M. M., Fertuzinhos, Sofia, Chen, Jie-Guang, Arellano, Jon I., Chan, Daniel W., Pletikos, Mihovil, Vasung, Lana, Rowitch, David H., Huang, Eric J., Schwartz, Michael L., Willemsen, Rob, Oostra, Ben A., Rakic, Pasko, Heffer, Marija, Kostović, Ivica, Judaš, Milos, Šestan, Nenad
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351852/
https://ncbi.nlm.nih.gov/pubmed/22579290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.060
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