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Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras mutated cancer cells

Oncogenic Ras mutations render the protein constitutively active and promote tumourigenisis via chronic stimulation of effector pathways. In A549 lung adenocarcinoma approximately 50% of the total Ras population is constitutively active yet these cells display only weak activation of the effectors:...

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Hlavní autoři: Omerovic, Jasminka, Clague, Michael J., Prior, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351670/
https://ncbi.nlm.nih.gov/pubmed/19922411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20091413
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