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Deregulation of DNA Damage Response Pathway by Intercellular Contact
Deregulation of the DNA damage response (DDR) pathway could compromise genomic integrity in normal cells and reduce cancer cell sensitivity to anticancer treatments. We found that intercellular contact stabilizes histone H2AX and γH2AX (H2AX phosphorylated on Ser-139) by up-regulating N/E-cadherin a...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3351312/ https://ncbi.nlm.nih.gov/pubmed/22431734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337212 |
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