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Deregulation of DNA Damage Response Pathway by Intercellular Contact

Deregulation of the DNA damage response (DDR) pathway could compromise genomic integrity in normal cells and reduce cancer cell sensitivity to anticancer treatments. We found that intercellular contact stabilizes histone H2AX and γH2AX (H2AX phosphorylated on Ser-139) by up-regulating N/E-cadherin a...

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Библиографические подробности
Главные авторы: Kang, Meyke Ausman, So, Eui-Young, Ouchi, Toru
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351312/
https://ncbi.nlm.nih.gov/pubmed/22431734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337212
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