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Deregulation of DNA Damage Response Pathway by Intercellular Contact

Deregulation of the DNA damage response (DDR) pathway could compromise genomic integrity in normal cells and reduce cancer cell sensitivity to anticancer treatments. We found that intercellular contact stabilizes histone H2AX and γH2AX (H2AX phosphorylated on Ser-139) by up-regulating N/E-cadherin a...

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書誌詳細
主要な著者: Kang, Meyke Ausman, So, Eui-Young, Ouchi, Toru
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351312/
https://ncbi.nlm.nih.gov/pubmed/22431734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337212
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