Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

Betaine-homocysteine S-methyltransferase (BHMT) catalyzes the synthesis of methionine from homocysteine. In our initial report, we observed a reduced body weight in Bhmt(−/−) mice. We initiated this study to investigate the potential role of BHMT in energy metabolism. Compared with the controls (Bhm...

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Autores principales: Teng, Ya-Wen, Ellis, Jessica M., Coleman, Rosalind A., Zeisel, Steven H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351280/
https://ncbi.nlm.nih.gov/pubmed/22362777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303255
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