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Deletion of Betaine-Homocysteine S-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas

Betaine-homocysteine S-methyltransferase (BHMT) uses betaine to catalyze the conversion of homocysteine (Hcy) to methionine. There are common genetic polymorphisms in the BHMT gene in humans that can alter its enzymatic activity. We generated the first Bhmt(−/−) mouse to model the functional effects...

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書誌詳細
主要な著者: Teng, Ya-Wen, Mehedint, Mihai G., Garrow, Timothy A., Zeisel, Steven H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196139/
https://ncbi.nlm.nih.gov/pubmed/21878621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.265348
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