Aphidicolin resistance in herpes simplex virus type I reveals features of the DNA polymerase dNTP binding site.

We describe the mapping and sequencing of mutations within the DNA polymerase gene of herpes simplex virus type 1 which confer resistance to aphidicolin, a DNA polymerase inhibitor. The mutations occur near two regions which are highly conserved among DNA polymerases related to the herpes simplex en...

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Hlavní autoři: Hall, J D, Wang, Y S, Pierpont, J, Berlin, M S, Rundlett, S E, Woodward, S
Médium: Artigo
Jazyk:Inglês
Vydáno: 1989
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC335127/
https://ncbi.nlm.nih.gov/pubmed/2555788
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