In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

The mechanism by which thrombotic vessel occlusion occurs independently of plaque development or endothelial cell (EC) disruption remains unclear, largely because of an inability to visualize the formation of thrombus, especially at the single-platelet level in real time. Here we demonstrate that ra...

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Autori principali: Nishimura, Satoshi, Manabe, Ichiro, Nagasaki, Mika, Kakuta, Shigeru, Iwakura, Yoichiro, Takayama, Naoya, Ooehara, Jun, Otsu, Makoto, Kamiya, Akihide, Petrich, Brian G., Urano, Tetsumei, Kadono, Takafumi, Sato, Shinichi, Aiba, Atsu, Yamashita, Hiroshi, Sugiura, Seiryo, Kadowaki, Takashi, Nakauchi, Hiromitsu, Eto, Koji, Nagai, Ryozo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351094/
https://ncbi.nlm.nih.gov/pubmed/22096246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381400
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