In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

The mechanism by which thrombotic vessel occlusion occurs independently of plaque development or endothelial cell (EC) disruption remains unclear, largely because of an inability to visualize the formation of thrombus, especially at the single-platelet level in real time. Here we demonstrate that ra...

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Détails bibliographiques
Auteurs principaux: Nishimura, Satoshi, Manabe, Ichiro, Nagasaki, Mika, Kakuta, Shigeru, Iwakura, Yoichiro, Takayama, Naoya, Ooehara, Jun, Otsu, Makoto, Kamiya, Akihide, Petrich, Brian G., Urano, Tetsumei, Kadono, Takafumi, Sato, Shinichi, Aiba, Atsu, Yamashita, Hiroshi, Sugiura, Seiryo, Kadowaki, Takashi, Nakauchi, Hiromitsu, Eto, Koji, Nagai, Ryozo
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Thrombosis and Hemostasis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351094/
https://ncbi.nlm.nih.gov/pubmed/22096246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381400
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