In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

The mechanism by which thrombotic vessel occlusion occurs independently of plaque development or endothelial cell (EC) disruption remains unclear, largely because of an inability to visualize the formation of thrombus, especially at the single-platelet level in real time. Here we demonstrate that ra...

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Bibliographic Details
Main Authors: Nishimura, Satoshi, Manabe, Ichiro, Nagasaki, Mika, Kakuta, Shigeru, Iwakura, Yoichiro, Takayama, Naoya, Ooehara, Jun, Otsu, Makoto, Kamiya, Akihide, Petrich, Brian G., Urano, Tetsumei, Kadono, Takafumi, Sato, Shinichi, Aiba, Atsu, Yamashita, Hiroshi, Sugiura, Seiryo, Kadowaki, Takashi, Nakauchi, Hiromitsu, Eto, Koji, Nagai, Ryozo
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351094/
https://ncbi.nlm.nih.gov/pubmed/22096246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-381400
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