Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype

BACKGROUND: We have identified syndecan-2 as a protein potentially involved in perineural invasion of pancreatic adenocarcinoma (PDAC) cells. METHODS: Syndecan-2 (SDC-2) expression was analyzed in human normal pancreas, chronic pancreatitis and PDAC tissues. Functional in vitro assays were carried o...

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Bibliografiske detaljer
Main Authors: De Oliveira, Tiago, Abiatari, Ivane, Raulefs, Susanne, Sauliunaite, Danguole, Erkan, Mert, Kong, Bo, Friess, Helmut, Michalski, Christoph W, Kleeff, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350462/
https://ncbi.nlm.nih.gov/pubmed/22471946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-19
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