A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

The interaction of acute myeloid leukemia (AML) blasts with the leukemic microenvironment is postulated to be an important mediator of resistance to chemotherapy and disease relapse. We hypothesized that inhibition of the CXCR4/CXCL12 axis by the small molecule inhibitor, plerixafor, would disrupt t...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Uy, Geoffrey L., Rettig, Michael P., Motabi, Ibraheem H., McFarland, Kyle, Trinkaus, Kathryn M., Hladnik, Lindsay M., Kulkarni, Shashikant, Abboud, Camille N., Cashen, Amanda F., Stockerl-Goldstein, Keith E., Vij, Ravi, Westervelt, Peter, DiPersio, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350358/
https://ncbi.nlm.nih.gov/pubmed/22308295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-383406
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky