A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

The interaction of acute myeloid leukemia (AML) blasts with the leukemic microenvironment is postulated to be an important mediator of resistance to chemotherapy and disease relapse. We hypothesized that inhibition of the CXCR4/CXCL12 axis by the small molecule inhibitor, plerixafor, would disrupt t...

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Detalhes bibliográficos
Main Authors: Uy, Geoffrey L., Rettig, Michael P., Motabi, Ibraheem H., McFarland, Kyle, Trinkaus, Kathryn M., Hladnik, Lindsay M., Kulkarni, Shashikant, Abboud, Camille N., Cashen, Amanda F., Stockerl-Goldstein, Keith E., Vij, Ravi, Westervelt, Peter, DiPersio, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350358/
https://ncbi.nlm.nih.gov/pubmed/22308295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-383406
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