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A DNA Binding Mutation in Estrogen Receptor-α Leads to Suppression of Wnt Signaling Via β-Catenin Destabilization in Osteoblasts
Estrogen receptors (ERs) play vital roles in the function and remodeling of bone. Their cellular mechanisms can broadly be categorized into those involving direct DNA binding (classical) or indirect DNA binding (non-classical). The generation of non-classical ER knock-in (ERα(−/NERKI)) mice provides...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349970/ https://ncbi.nlm.nih.gov/pubmed/22573547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24095 |
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