A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells

Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways Analysis™, we identified genes (up- or down-regulated, ≥ 1.5 fold, P ≤ 0.001), functions and signaling pathways...

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Main Authors: Di, Xudong, Andrews, Danica M.K., Tucker, Charles J., Yu, Linda, Moore, Alicia B., Zheng, Xiaolin, Castro, Lysandra, Hermon, Tonia, Xiao, Hang, Dixon, Darlene
Formáid: Artigo
Teanga:Inglês
Foilsithe: Korean Society for Biochemistry and Molecular Biology 2012
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349910/
https://ncbi.nlm.nih.gov/pubmed/22228119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2012.44.4.024
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