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A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells

Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways Analysis™, we identified genes (up- or down-regulated, ≥ 1.5 fold, P ≤ 0.001), functions and signaling pathways...

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Detalhes bibliográficos
Main Authors: Di, Xudong, Andrews, Danica M.K., Tucker, Charles J., Yu, Linda, Moore, Alicia B., Zheng, Xiaolin, Castro, Lysandra, Hermon, Tonia, Xiao, Hang, Dixon, Darlene
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349910/
https://ncbi.nlm.nih.gov/pubmed/22228119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2012.44.4.024
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