Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture

BACKGROUND: Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated the interactions between human uterine leiomyoma (UtLM) cells and uterine leiomyoma-derived fibroblasts (FB), and their importan...

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Autori principali: Moore, Alicia B, Yu, Linda, Swartz, Carol D, Zheng, Xaiolin, Wang, Lu, Castro, Lysandra, Kissling, Grace E, Walmer, David K, Robboy, Stanley J, Dixon, Darlene
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897788/
https://ncbi.nlm.nih.gov/pubmed/20537183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-8-10
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