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TGF-β Promotes Proliferation of Thyroid Epithelial Cells in IFN-γ(−/−) Mice by Down-Regulation of p21 and p27 via AKT Pathway
IFN-γ(−/−) NOD.H-2h4 mice develop an autoimmune disease characterized by hyperplasia and proliferation of thyroid epithelial cells (TEC H/P). Proliferating TECs produce TGF-β, and IFN-γ inhibits TEC H/P. In the present study, cultured TECs were used to directly determine the mechanisms by which thes...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349845/ https://ncbi.nlm.nih.gov/pubmed/22119715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.10.009 |
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