The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein

The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccines containing recombinant fHbp or native outer memb...

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Bibliografiska uppgifter
Huvudupphovsmän: Beernink, Peter T., Shaughnessy, Jutamas, Pajon, Rolando, Braga, Emily M., Ram, Sanjay, Granoff, Dan M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349754/
https://ncbi.nlm.nih.gov/pubmed/22589720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002688
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