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An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers

Genome-wide association studies (GWAS) have repeatedly shown an association between non-coding variants in the TCF7L2 locus and risk for type 2 diabetes (T2D), implicating a role for cis-regulatory variation within this locus in disease etiology. Supporting this hypothesis, we previously localized c...

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Bibliografske podrobnosti
Main Authors: Savic, Daniel, Bell, Graeme I., Nobrega, Marcelo A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349716/
https://ncbi.nlm.nih.gov/pubmed/22590553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036501
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