Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways

The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor. Nicastrin (NCT) is an essential component of the gamma-secretase complex and functions as a receptor for gamma-secretase substrates....

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Bibliographische Detailangaben
Hauptverfasser: Mo, Jung-Soon, Yoon, Ji-Hye, Hong, Ji-Ae, Kim, Mi-Yeon, Ann, Eun-Jung, Ahn, Ji-Seon, Kim, Su-Man, Baek, Hyeong-Jin, Lang, Florian, Choi, Eui-Ju, Park, Hee-Sae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349648/
https://ncbi.nlm.nih.gov/pubmed/22590650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037111
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