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Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats

Phosphodiesterase (PDE) 4 inhibitors are potent anti-inflammatory drugs with antihypertensive properties, and their therapeutic role in bronchopulmonary dysplasia (BPD) is still controversial. We studied the role of PDE4 inhibition with piclamilast on normal lung development and its therapeutic valu...

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Detalhes bibliográficos
Main Authors: de Visser, Yvonne P., Walther, Frans J., Laghmani, El Houari, Steendijk, Paul, Middeldorp, Maaike, van der Laarse, Arnoud, Wagenaar, Gerry T. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349366/
https://ncbi.nlm.nih.gov/pubmed/21949154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00041.2011
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