Human apolipoprotein E genotypes differentially modify house dust mite-induced airway disease in mice

Apolipoprotein E (apoE) is an endogenous negative regulator of airway hyperreactivity (AHR) and mucous cell metaplasia in experimental models of house dust mite (HDM)-induced airway disease. The gene encoding human apoE is polymorphic, with three common alleles (ε2, ε3, and ε4) reflecting single ami...

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Autori principali: Yao, Xianglan, Dai, Cuilian, Fredriksson, Karin, Lam, Jonathan, Gao, Meixia, Keeran, Karen J., Nugent, Gayle Zywicke, Qu, Xuan, Yu, Zu-Xi, Jeffries, Neal, Lin, JingPing, Kaler, Maryann, Shamburek, Robert, Costello, Rene, Csako, Gyorgy, Dahl, Morten, Nordestgaard, Børge G., Remaley, Alan T., Levine, Stewart J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349362/
https://ncbi.nlm.nih.gov/pubmed/22058162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00110.2011
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