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5-Aminoimidazole-4-carboxyamide Ribonucleoside Induces G1/S Arrest and Nanog Downregulation via p53 and Enhances Erythroid Differentiation

Molecular mechanisms of how energy metabolism affects embryonic stem (ES) cell pluripotency remain unclear. AMP-activated protein kinase (AMPK), a key regulator for controlling energy metabolism, is activated in response to ATP-exhausting stress. We investigated whether cellular energy homeostasis i...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Chae, Hee-Don, Lee, Man Ryul, Broxmeyer, Hal E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349353/
https://ncbi.nlm.nih.gov/pubmed/22076938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.778
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