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Fluid shear stress inhibits TNF-α activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members

Atherosclerosis preferentially occurs in areas of turbulent flow and low fluid shear stress, whereas laminar flow and high shear stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and IL-1 stimulate expression of endothelial cell (EC) genes that may promote...

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Detalhes bibliográficos
Main Authors: Surapisitchat, James, Hoefen, Ryan J., Pi, Xinchun, Yoshizumi, Masanori, Yan, Chen, Berk, Bradford C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC33493/
https://ncbi.nlm.nih.gov/pubmed/11353829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101134098
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