Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin Signaling Pathway in Caenorhabditis elegans

Clozapine has superior and unique effects as an antipsychotic agent, but the mediators of these effects are not known. We studied behavioral and developmental effects of clozapine in Caenorhabditis elegans, as a model system to identify previously undiscovered mechanisms of drug action. Clozapine in...

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Autori principali: Karmacharya, Rakesh, Sliwoski, Gregory R., Lundy, Miriam Y., Suckow, Raymond F., Cohen, Bruce M., Buttner, Edgar A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348699/
https://ncbi.nlm.nih.gov/pubmed/19322168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.35
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