A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target

We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor screen for antipsychotic drug (APD) targets in an animal. The screen identifies 40 suppressors, including the α-like nicotini...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Saur, Taixiang, DeMarco, Sarah E., Ortiz, Angelica, Sliwoski, Gregory R., Hao, Limin, Wang, Xin, Cohen, Bruce M., Buttner, Edgar A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585123/
https://ncbi.nlm.nih.gov/pubmed/23468647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003313
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados