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P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells

Rho GTPases are overexpressed and hyperactivated in many cancers, including breast cancer. Rho proteins, as well as their regulators and effectors, have been implicated in mitosis, and their altered expression promotes mitotic defects and aneuploidy. Previously, we demonstrated that p190B Rho GTPase...

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Autors principals: Hwang, Melissa, Peddibhotla, Sirisha, McHenry, Peter, Chang, Peggy, Yochum, Zachary, Park, Ko Un, Sears, James Cooper, Vargo-Gogola, Tracy
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348653/
https://ncbi.nlm.nih.gov/pubmed/22582143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers4020475
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