Overexpression of p27(Kip1) lengthens the G(1) phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells

We describe a mouse model in which p27(Kip1) transgene expression is spatially restricted to the central nervous system neuroepithelium and temporally controlled with doxycycline. Transgene-specific transcripts are detectable within 6 h of doxycycline administration, and maximum nonlethal expression...

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Detalhes bibliográficos
Main Authors: Mitsuhashi, Takayuki, Aoki, Yoko, Eksioglu, Yaman Z., Takahashi, Takao, Bhide, Pradeep G., Reeves, Steven A., Caviness, Verne S.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC33486/
https://ncbi.nlm.nih.gov/pubmed/11371649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111051398
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