dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies

Sir2 is an evolutionarily conserved NAD(+) dependent protein. Although, SIRT1 has been implicated to be a key regulator of fat and glucose metabolism in mammals, the role of Sir2 in regulating organismal physiology, in invertebrates, is unclear. Drosophila has been used to study evolutionarily conse...

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Hlavní autoři: Banerjee, Kushal Kr., Ayyub, Champakali, Sengupta, Samudra, Kolthur-Seetharam, Ullas
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348481/
https://ncbi.nlm.nih.gov/pubmed/22411915
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